Transcriptional Control of the Bradyrhizobium japonicum irr Gene Requires Repression by Fur and Antirepression by Irr

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Positive control of ferric siderophore receptor gene expression by the Irr protein in Bradyrhizobium japonicum.

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Fur-independent regulation of iron metabolism by Irr in Bradyrhizobium japonicum.

Bradyrhizobium japonicum expresses both Fur and Irr, proteins that mediate iron-dependent regulation of gene expression. Control of irr mRNA accumulation by iron was aberrant in a fur mutant strain, and Fur repressed an irr::lacZ promoter fusion in the presence of iron. Furthermore, metal-dependent binding of Fur to an irr gene promoter was demonstrated in a region with no significant similarit...

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The Bradyrhizobium japonicum Irr protein is a transcriptional repressor with high-affinity DNA-binding activity.

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 2010

ISSN: 0021-9258

DOI: 10.1074/jbc.m110.145979